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Structure-activity relationships of anti-HIV-1 N-alkoxy- and N-allyloxy-benzimidazoles

✍ Scribed by Tahnee M. Evans; John M. Gardiner; Naheed Mahmood; Marilyne Smis

Book ID: 104364837
Publisher: Elsevier Science
Year: 1997
Tongue: English
Weight: 226 KB
Volume: 7
Category: Article
ISSN: 0960-894X
DOI: 10.1016/s0960-894x(97)00022-x

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✦ Synopsis

One-pot benzimidazole syntheses have been used to prepare an extended series of novel analogues which were evaluated against HIV-1 infectivity, the most active having an EC50 of 0.5~tM. There is a con'elation between the length of saturated alkyl groups at O1 and C2 with antiviral selectivity. Replacing vinyl by the 2,2-dimethyl vinyl group increases antiviral selectivity.

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