Synthesis, structure and properties of N-alkoxy-N-(1-pyridinium)urea salts, N-alkoxy-N-acyloxyureas and N,N-dialkoxyureas
β Scribed by Vasiliy G. Shtamburg; Oleg V. Shishkin; Roman I. Zubatyuk; Svetlana V. Kravchenko; Alexander V. Tsygankov; Victor V. Shtamburg; Vitaliy B. Distanov; Remir G. Kostyanovsky
- Book ID
- 104056336
- Publisher
- Royal Society of Chemistry
- Year
- 2007
- Tongue
- English
- Weight
- 465 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0959-9436
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One-pot benzimidazole syntheses have been used to prepare an extended series of novel analogues which were evaluated against HIV-1 infectivity, the most active having an EC50 of 0.5~tM. There is a con'elation between the length of saturated alkyl groups at O1 and C2 with antiviral selectivity. Repla
## Abstract The complete manuscript of this communication appears in: __Angew. Chem. Suppl. 1983__, 264. DOI:10.1002/anie.198302640