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Structure-Activity Relationships of an Anti-HIV Peptide, T22

✍ Scribed by H. Tamamura; T. Murakami; M. Masuda; A. Otaka; W. Takada; T. Ibuka; H. Nakashima; M. Waki; A. Matsumoto; N. Yamamoto; N. Fujii


Book ID
115575894
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
364 KB
Volume
205
Category
Article
ISSN
0006-291X

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Structure-activity relationships of anti
✍ Tahnee M. Evans; John M. Gardiner; Naheed Mahmood; Marilyne Smis πŸ“‚ Article πŸ“… 1997 πŸ› Elsevier Science 🌐 English βš– 226 KB

One-pot benzimidazole syntheses have been used to prepare an extended series of novel analogues which were evaluated against HIV-1 infectivity, the most active having an EC50 of 0.5~tM. There is a con'elation between the length of saturated alkyl groups at O1 and C2 with antiviral selectivity. Repla