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Structure-Activity Relationships in a Series of Anticonvulsant and Hypnotic Bicyclic Carboxamides
✍ Scribed by Boehme, Werner R.; Siegmund, Estelle A.; Scharpf, William G.; Schipper, Edgar.
- Book ID
- 127126569
- Publisher
- American Chemical Society
- Year
- 1962
- Tongue
- English
- Weight
- 754 KB
- Volume
- 5
- Category
- Article
- ISSN
- 0022-2623
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Valpromide (VPD) and valnoctamide (VCD) are two isomers which are aliphatic amides derived from short fatty acids that possess anticonvulsant activity. Our previous studies with VPD, VCD, and other related compounds showed that the biotransformation of these amides to their respective homologous ac
The structures of 7-0x0-1-azabicyclo [ 3.2.01 heptane and its 4-oxa, 3-ethylene-4-oxa, and 3-ethylene-6-methyl-4-oxa derivatives, and of 8-0x0-1-azabicyclo [ 4.2.01 octane and its 5oxa derivative, were studied by ah initio methods. Conformations were refined without constraints using the 4-21G and t