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Structure--Activity Relationships in a Series of Antiarrhythmic and Local Anaesthetic Bicyclic Glycinamides

✍ Scribed by Boehme, Werner R.; Graeme, Mary Lee; Scharpf, William G.; Siegmund, Estelle; Schipper, Edgar; Tobkes, Martin


Book ID
120333715
Publisher
American Chemical Society
Year
1961
Tongue
English
Weight
870 KB
Volume
4
Category
Article
ISSN
0022-2623

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The structures of 7-0x0-1-azabicyclo [ 3.2.01 heptane and its 4-oxa, 3-ethylene-4-oxa, and 3-ethylene-6-methyl-4-oxa derivatives, and of 8-0x0-1-azabicyclo [ 4.2.01 octane and its 5oxa derivative, were studied by ah initio methods. Conformations were refined without constraints using the 4-21G and t