𝔖 Bobbio Scriptorium
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Structure - activity relationship of melatonin analogues

✍ Scribed by M.A. Frohn; C.J. Seaborn; D.W. Johnson; G. Phillipou; R.F. Seamark; C.D. Matthews

Book ID
118939886
Publisher
Elsevier Science
Year
1980
Tongue
English
Weight
219 KB
Volume
27
Category
Article
ISSN
0024-3205

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Four novel ustiloxin D analogues were synthesized focusing on the size of the macrocyclic core, the stereochemistry at the bridgehead ether, and the enantiomer of ustiloxin D. All four were subjected to biological evaluation testing the inhibition of tubulin polymerization. Only 2,2-dimethyl-ustilox