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Structure-activity profiles of macrolactam immunosuppressant FK-506 analogues

โœ Scribed by Megumi Kawai; Benjamin C. Lane; Gin C. Hsieh; Karl W. Mollison; George W. Carter; Jay R. Luly

Book ID
115928284
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
857 KB
Volume
316
Category
Article
ISSN
0014-5793

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Beckmann rearrangement of FK506 E-oxime gave amide 2 and the fragmentation product 4. Compound 4 was atso prepared by total synthesis. The immunosuppressant FK506 has been the subject of considerabie synthetic' and degradative2 studies. As part of our pmgramme in this area we investigated the stNdU