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Structure of FK506, a novel immunosuppressant isolated from Streptomyces

โœ Scribed by Tanaka, Hirokazu; Kuroda, Akio; Marusawa, Hiroshi; Hatanaka, Hiroshi; Kino, Toru; Goto, Toshio; Hashimoto, Masashi; Taga, Toru

Book ID
120333696
Publisher
American Chemical Society
Year
1987
Tongue
English
Weight
366 KB
Volume
109
Category
Article
ISSN
0002-7863

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Distribution kinetics of FK-506, a novel
Distribution kinetics of FK-506, a novel immunosuppressant, after intravenous administration to rats in comparison with cyclosporin A
โœ Kanji Takada; Hisato Usuda; Mamoru Oh-Hashi ๐Ÿ“‚ Article ๐Ÿ“… 1992 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 588 KB

The distribution kinetics of a novel potent immunosuppressant, FK-506 (FK) has been studied in comparison with cyclosporin A (CyA) both in vivo and in vitro using blood specimens. The infusion studies on FK, 5.0mg kg-1 through the portal and femoral veins showed that the mean hepatic extraction rati