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Structural Organization of A Multifunctional Polyketide Synthase Involved in the Biosynthesis of the Macrolide Immunosuppressant FK506

✍ Scribed by Haideh Motamedi; Sheng-Jian Cai; Ali Shafiee; Keith O. Elliston


Book ID
115132326
Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
720 KB
Volume
244
Category
Article
ISSN
1432-1327

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As a novel superfamily of type III polyketide synthases in microbes, four genes csyA, csyB, csyC, and csyD, were found in the genome of Aspergillus oryzae, an industrially important filamentous fungus. In order to analyze their functions, we carried out the overexpression of csyA under the control o