Structural studies of some 5-(perfluoroalkenyl) uracils
β Scribed by Henryk Koroniak; Piotr Fiedorow; Donata Pluskota; Piotr Karwatka; Khalil A. Abboud
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 570 KB
- Volume
- 323
- Category
- Article
- ISSN
- 0022-2860
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5-(1-Hydroxyethyl)uracil, prepared by the reduction of 5-acetyluracil with sodium borohydride, has been dehydrated with formic acid to give 5-vinyluracil and a dimer of 5-vinyluracil, trans 1,3-bis (uracil-5-yl)but-l-ene. These compounds have also been prepared with a tritium label in an identified
## Abstract The synthesis of 5β[^3^Hβethynyl]uracil and 5βacetyl[6β^3^H]uracil in good yield and of a medium specific activity ( > 40 mCi/mmol) is described. The compounds are necessary for following the incorporation of these and other derived 5βsubstituted uracils into DNA and also for studying t