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Structural requirements for high activity of propafenone-type modulators of multidrug resistance

✍ Scribed by G. Ecker; P. Chiba; K.-J. Schaper; W. Fleischhacker


Book ID
117628665
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
69 KB
Volume
4
Category
Article
ISSN
0928-0987

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Studies on Propafenone-type Modulators o
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A series of 5-hydroxy and 5-benzyloxy analogs of the antiarrhythmic and multidrug resistance (MDR) modulating drug propafenone was synthesized and the MDR-modulating activity of the compounds was evaluated using a daunomycin efflux assay system. The key step of the synthesis is the selective reducti