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Synthesis and multidrug resistance modulating activity of 5-hydroxy-propafenone analogs

✍ Scribed by B. Teil; M. Hizler; W. Jäger; [. Chiba; G. Ecker; W. Fleischhacker

Book ID
117628696
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
134 KB
Volume
4
Category
Article
ISSN
0928-0987

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✍ Peter Chiba; Barbara Tell; Walter Jäger; Elisabeth Richter; Manuela Hitzlera; Ge 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 510 KB

A series of 5-hydroxy and 5-benzyloxy analogs of the antiarrhythmic and multidrug resistance (MDR) modulating drug propafenone was synthesized and the MDR-modulating activity of the compounds was evaluated using a daunomycin efflux assay system. The key step of the synthesis is the selective reducti