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A Comparative Molecular Field Analysis of Propafenone-type Modulators of Cancer Multidrug Resistance

✍ Scribed by Pajeva, Ilza K. ;Wiese, Michael


Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
939 KB
Volume
17
Category
Article
ISSN
1611-020X

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A series of 5-hydroxy and 5-benzyloxy analogs of the antiarrhythmic and multidrug resistance (MDR) modulating drug propafenone was synthesized and the MDR-modulating activity of the compounds was evaluated using a daunomycin efflux assay system. The key step of the synthesis is the selective reducti