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Structural properties of the nickel ions in urease: novel insights into the catalytic and inhibition mechanisms

✍ Scribed by Stefano Ciurli; Stefano Benini; Wojciech R. Rypniewski; Keith S. Wilson; Silvia Miletti; Stefano Mangani

Publisher: Elsevier Science
Year: 1999
Tongue: English
Weight: 472 KB
Volume: 190-192
Category: Article
ISSN: 0010-8545
DOI: 10.1016/s0010-8545(99)00093-4

No coin nor oath required. For personal study only.

✦ Synopsis

relationships between the structural features of the Ni-containing active site and the physico-chemical and biochemical properties of this metallo-enzyme. In addition, the recently determined structure of a complex between urease and a transition state analogue is discussed as it leads to a novel, thought-provoking proposal for the enzyme mechanism.

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