✦ LIBER ✦

New insight into the mechanism of catalytic hydrogenation allows the structure of the key intermediate in asymmetric hydrogenation to be predicted

✍ Scribed by Jinquan Yu; Jonathan B. Spencer

Publisher: Elsevier Science
Year: 1998
Tongue: French
Weight: 616 KB
Volume: 54
Category: Article
ISSN: 0040-4020
DOI: 10.1016/s0040-4020(98)00992-2

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✦ Synopsis

An approach has been developed to determine the regioselectivity of hydrometalation in homogeneous and heterogeneous hydrogenation of alkenes. By studying the electronic effects on the orientation of hydrometalation it is found with palladium and rhodium that this key step is a two electron process that can occur by two modes (a Pd 8+-H 8-or b Pd ~'-Hf~+). This provides valuable information about the structure of the metal-alkyl intermediate and helps rationalise how chiral induction occurs.

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