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Structural Identification of the Degradation Products of the Antitumor Peptide Antagonist [Arg6,D-Trp7,9,MePhe8]Substance P (6-11)

โœ Scribed by Reubsaet, J. Leon E.; Beijnen, Jos H.; Bult, Auke.; Hop, Ed.; Vermaas, Raymond.; Kellekule, Yunus.; Kettenes-van den Bosch, J. Jantien.; Underberg, Willy J. M.


Book ID
127243459
Publisher
American Chemical Society
Year
1995
Tongue
English
Weight
585 KB
Volume
67
Category
Article
ISSN
0003-2700

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Antagonist \(\left[\mathrm{Arg}^{6}\right.\), D-Trp \({ }^{7,9}\), MePhe \(\left.^{8}\right]\)-substance P \{611) was subjected to a systematic stability study in which kinetic parameters were obtained for the degradation of this hexapeptide under several well-defined conditions. The influences of \

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Reversed-phase high-performance liquid chromatography and capillary zone electrophoresis are widely used in protein and peptide analysis. Degradation of the basic peptide \(\left[\right.\) Arg \(^{6}\), D-Trp \({ }^{7,9}\), MePhe \(\left.^{8}\right]\)-substance P \(\{6-\) 11 (antagonist G) was monit