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Determination of two neuropeptide growth factor antagonists, [d-Arg1,d-Phe5,d-Trp7,9,Leu11]-substance P and [Arg6, d-Trp7,9,N-MePhe8]-substance P(6–11), by high-performance liquid chromatography with electrochemical detection

✍ Scribed by Jeffrey Cummings; Alexander MacLellan; Simon P. Langdon; Enrique Rozengurt; John F. Smyth

Book ID
103804914
Publisher
Elsevier Science
Year
1994
Weight
661 KB
Volume
653
Category
Article
ISSN
0378-4347

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Reversed-Phase High-Performance Liquid C
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✍ J.L.E. Reubsaet; J.H. Beijnen; A. Bult; J. Teeuwsen; E.H.M. Koster; J.C.M. Water 📂 Article 📅 1994 🏛 Elsevier Science 🌐 English ⚖ 409 KB

Reversed-phase high-performance liquid chromatography and capillary zone electrophoresis are widely used in protein and peptide analysis. Degradation of the basic peptide \(\left[\right.\) Arg \(^{6}\), D-Trp \({ }^{7,9}\), MePhe \(\left.^{8}\right]\)-substance P \(\{6-\) 11 (antagonist G) was monit

[D-Arg1, D-Phe5,D-Trp7,9,Leu11] substanc
[D-Arg1, D-Phe5,D-Trp7,9,Leu11] substance P, a neuropeptide antagonist, blocks binding, Ca2+-mobilizing, and mitogenic effects of endothelin and vasoactive intestinal contractor in mouse 3T3 cells
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SEM of five determinations, corresponding to two different experiments. Results are expressed as percentage of L3HI-thymidine incorporation obtained in the absence of inhibitor.