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Structural features of heparin variants having high anti-Xa clotting-activity

✍ Scribed by Lars-Åke Fransson; Birgitta Havsmark; Ian A. Nieduszynski; Thomas N. Huckerby; Walter E. Lewis

Book ID
108308094
Publisher
Elsevier Science
Year
1982
Tongue
English
Weight
506 KB
Volume
104
Category
Article
ISSN
0008-6215

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✍ Hans Peter Wessel; Ludvik Labler; Thomas B. Tschopp 📂 Article 📅 1989 🏛 John Wiley and Sons 🌐 German ⚖ 714 KB

The synthesis of tri-N-acetylated heparin pentasaccharide 2 is described. It was assembled from five suitably blocked monosaccharide units (S7). Glucuronic-acid building block 4 was prepared from glucose by direct Jones oxidation of the 6-0-trityl derivative 18. The resulting acid 16 was esterified