The specific capsular polysaccharide of Streptococcus pneumoniae type 18C (56) contains D-glucose, D-galactose, L-rhamnose, and glycerol residues, and phosphate and O-acetyl groups in the molar ratios of 3:1:1:1:1:1. Accumulated data from methylation analyses of the native and the specifically degra
Structural determination of the capsular polysaccharide of Streptococcus pneumoniae type 19A (57)
β Scribed by Ewa Katzenellenbogen; Harold J. Jennings
- Publisher
- Elsevier Science
- Year
- 1983
- Tongue
- English
- Weight
- 714 KB
- Volume
- 124
- Category
- Article
- ISSN
- 0008-6215
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β¦ Synopsis
The structure of the Pneumococcus type 19A (57) capsular polysaccharide has been reinvestigated by using methylation analysis and n.m.r. spectroscopy. It is composed of residues of 2-acetamido-2-deoxy-D-mannose, D-glUCOSe, L-rhamnose, and phosphate in the molar ratios of 1:l: 1:l. The polysaccharide is linear, and is composed of these components in a repeating unit of the following structure.
The type 19A polysaccharide (Na+ salt) was depolymerized by heating it in water at loo", conditions that also hydrolyzed the newly formed phosphoric monoesters.
'The Danish system of nomenclature, followed by the U.S. system in parentheses, is used throughout. **N.R.C.C. No. 22613.
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