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Structural determination of the capsular polysaccharide of Streptococcus pneumoniae type 19A (57)

✍ Scribed by Ewa Katzenellenbogen; Harold J. Jennings


Publisher
Elsevier Science
Year
1983
Tongue
English
Weight
714 KB
Volume
124
Category
Article
ISSN
0008-6215

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✦ Synopsis


The structure of the Pneumococcus type 19A (57) capsular polysaccharide has been reinvestigated by using methylation analysis and n.m.r. spectroscopy. It is composed of residues of 2-acetamido-2-deoxy-D-mannose, D-glUCOSe, L-rhamnose, and phosphate in the molar ratios of 1:l: 1:l. The polysaccharide is linear, and is composed of these components in a repeating unit of the following structure.

The type 19A polysaccharide (Na+ salt) was depolymerized by heating it in water at loo", conditions that also hydrolyzed the newly formed phosphoric monoesters.

'The Danish system of nomenclature, followed by the U.S. system in parentheses, is used throughout. **N.R.C.C. No. 22613.


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