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Structural basis of nuclear import of flap endonuclease 1 (FEN1)

✍ Scribed by de Barros, Andrea C. ;Takeda, Agnes A. S. ;Chang, Chiung-Wen ;Kobe, Boštjan ;Fontes, Marcos R. M.


Book ID
114529002
Publisher
International Union of Crystallography
Year
2012
Tongue
English
Weight
658 KB
Volume
68
Category
Article
ISSN
0907-4449

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The products of proliferating cell nuclear antigen (PCNA) and flap endonuclease (FEN1) genes are multifunctional proteins that are involved in DNA replication and damage repair. Yeast models suggest association of mutant forms of PCNA and FEN1 with genomic instability. In our study, we have determin