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Structural basis for recruitment of human flap endonuclease 1 to PCNA

✍ Scribed by Sakurai, Shigeru; Kitano, Ken; Yamaguchi, Hiroto; Hamada, Keisuke; Okada, Kengo; Fukuda, Kotaro; Uchida, Makiyo; Ohtsuka, Eiko; Morioka, Hiroshi; Hakoshima, Toshio


Book ID
110030915
Publisher
Nature Publishing Group
Year
2004
Tongue
English
Weight
667 KB
Volume
24
Category
Article
ISSN
0261-4189

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The products of proliferating cell nuclear antigen (PCNA) and flap endonuclease (FEN1) genes are multifunctional proteins that are involved in DNA replication and damage repair. Yeast models suggest association of mutant forms of PCNA and FEN1 with genomic instability. In our study, we have determin