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Sequence of human FEN-1, a structure-specific endonuclease, and chromosomal localization of the gene (FEN1) in mouse and human

✍ Scribed by Lea R. Hiraoka; John J. Harrington; Daniela S. Gerhard; Michael R. Lieber; Chih-Lin Hsieh


Book ID
116154057
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
662 KB
Volume
25
Category
Article
ISSN
0888-7543

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The products of proliferating cell nuclear antigen (PCNA) and flap endonuclease (FEN1) genes are multifunctional proteins that are involved in DNA replication and damage repair. Yeast models suggest association of mutant forms of PCNA and FEN1 with genomic instability. In our study, we have determin