✦ LIBER ✦

Structural Basis of Chemokine Receptor Function—A Model for Binding Affinity and Ligand Selectivity

✍ Scribed by Lavanya Rajagopalan; Krishna Rajarathnam

Publisher: Springer
Year: 2006
Tongue: English
Weight: 602 KB
Volume: 26
Category: Article
ISSN: 0144-8463
DOI: 10.1007/s10540-006-9025-9

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Modeling the Structural Basis of Human C

Modeling the Structural Basis of Human CCR5 Chemokine Receptor Function: From Homology Model Building and Molecular Dynamics Validation to Agonist and Antagonist Docking.

✍ A. Fano; D. W. Ritchie; A. Carrieri 📂 Article 📅 2006 🏛 John Wiley and Sons ⚖ 8 KB 👁 1 views

Structural basis for the cyclophilin A b

Structural basis for the cyclophilin A binding affinity and immunosuppressive potency of E-ISA247 (voclosporin)

✍ Kuglstatter, Andreas ;Mueller, Francis ;Kusznir, Eric ;Gsell, Bernard ;Stihle, M 📂 Article 📅 2011 🏛 International Union of Crystallography 🌐 English ⚖ 469 KB

X-ray crystal structures of the cyclosporin A analogue __E__-ISA247 (voclosporin) and its stereoisomer __Z__-ISA247 bound to cyclophilin A suggest the molecular basis for the differences in their binding affinities and immunosuppressive efficacies.

ChemInform Abstract: Structure-Based App

ChemInform Abstract: Structure-Based Approach for the Study of Estrogen Receptor Binding Affinity and Subtype Selectivity.

✍ Livia B. Salum; Igor Polikarpov; Adriano D. Andricopulo 📂 Article 📅 2009 🏛 John Wiley and Sons ⚖ 21 KB 👁 2 views

A nonpeptidic agonist ligand of the huma

A nonpeptidic agonist ligand of the human C5a receptor: Synthesis, binding affinity optimization and functional characterization

✍ S.E. de Laszlo; E.E. Allen; B. Li; D. Ondeyka; R. Rivero; L. Malkowitz; C. Molin 📂 Article 📅 1997 🏛 Elsevier Science 🌐 English ⚖ 297 KB

The structural optimization for binding affinity and attempted modification of agonist function of a nonpeptide ligand of the human C5a receptor is described.

Molecular characterization of the chemok

Molecular characterization of the chemokine receptor CXCR3: evidence for the involvement of distinct extracellular domains in a multi-step model of ligand binding and receptor activation

✍ Georgina Xanthou; Timothy J. Williams; James E. Pease 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 289 KB 👁 1 views

Trishomocubanes, a new class of selectiv

Trishomocubanes, a new class of selective and high affinity ligands for the sigma binding site

✍ Michael Kassiou; Vu H. Nguyen; Robert Knott; MacDonald J. Christie; Trevor W. Ha 📂 Article 📅 1996 🏛 Elsevier Science 🌐 English ⚖ 279 KB

The synthesis, receptor binding, and preliminary structural characterisation of trishomocubanes of types pentacyclo [5.4.0.02'6.03'l°.05'9]undecylamines and 4-azahexacyclo[5.4.1.0E'6.03'l°.05'9.08'll]dodecanes are described. These ligands demonstrated high selectivity and affinity for the sigma bind