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Structural basis for the cyclophilin A binding affinity and immunosuppressive potency of E-ISA247 (voclosporin)

✍ Scribed by Kuglstatter, Andreas ;Mueller, Francis ;Kusznir, Eric ;Gsell, Bernard ;Stihle, Martine ;Thoma, Ralf ;Benz, Joerg ;Aspeslet, Launa ;Freitag, Derrick ;Hennig, Michael

Publisher: International Union of Crystallography
Year: 2011
Tongue: English
Weight: 469 KB
Volume: 67
Category: Article
ISSN: 0907-4449
DOI: 10.1107/s0907444910051905

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✦ Synopsis

X-ray crystal structures of the cyclosporin A analogue E-ISA247 (voclosporin) and its stereoisomer Z-ISA247 bound to cyclophilin A suggest the molecular basis for the differences in their binding affinities and immunosuppressive efficacies.

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