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Structural basis for the interaction of [E160A–E189A]-trichosanthin with adenine

✍ Scribed by Pang-Chui Shaw; Kam-Bo Wong; Denise S.-B Chan; Roger L Williams

Book ID
117227597
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
344 KB
Volume
41
Category
Article
ISSN
0041-0101

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X-ray crystal structures of the cyclosporin A analogue __E__-ISA247 (voclosporin) and its stereoisomer __Z__-ISA247 bound to cyclophilin A suggest the molecular basis for the differences in their binding affinities and immunosuppressive efficacies.