Structural aspects of phenoxyalkanoic acids. X. Bis(2-chlorophenoxy)acetic acid and bis(4-chlorophenoxy)acetic acid
✍ Scribed by Smith, G. ;Kennard, C. H. L.
- Book ID
- 114527967
- Publisher
- International Union of Crystallography
- Year
- 1981
- Weight
- 507 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0567-7408
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## Abstract Phenylacetic acid mustard (PAM; **2**), a major metabolite of the anticancer agent chlorambucil (CLB; **1**), was allowed to react with 2′‐deoxyadenosine (dA), 2′‐deoxyguanosine (dG), 2′‐deoxycytidine (dC), 2′‐deoxy‐5‐methylcytidine (dMeC), and thymidine (T) at physiological pH (cacodyl
2,2-Bis(4-chlorophenyl) acetic acid (DDA) was extracted from acidified urine at pH 2 by benzene. It was complexed by partitioning with crystal violet in acetic acid to yield a blue color which was quantitated at 6 10 nm. Its identity was conlirrned by paper chromatographic separation. The DDA excret