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Structural and stoichiometric determinants of Ca2+ release-activated Ca2+ (CRAC) channel Ca2+-dependent inactivation

✍ Scribed by Scrimgeour, Nathan R.; Wilson, David P.; Barritt, Greg J.; Rychkov, Grigori Y.


Book ID
121693764
Publisher
Elsevier Science
Year
2014
Tongue
English
Weight
631 KB
Volume
1838
Category
Article
ISSN
0005-2736

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We measured the activity of the Ca 2Ο© release-activated Ca 2Ο© (CRAC) channel present in cultured rat microglia, using the whole-cell mode of patch clamp technique. When the concentration of divalent cations in external solution was reduced to the micromolar range, and Ca 2Ο© chelating agent BAPTA was