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Ca2+release-activated Ca2+(CRAC) current, structure, and function

✍ Scribed by Martin Muik, Rainer Schindl, Marc Fahrner…


Book ID
120742989
Publisher
Springer
Year
2012
Tongue
English
Weight
598 KB
Volume
69
Category
Article
ISSN
1420-682X

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We measured the activity of the Ca 2ϩ release-activated Ca 2ϩ (CRAC) channel present in cultured rat microglia, using the whole-cell mode of patch clamp technique. When the concentration of divalent cations in external solution was reduced to the micromolar range, and Ca 2ϩ chelating agent BAPTA was