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Structural and functional analysis of hypoxia-inducible factor 1

✍ Scribed by Semenza, Gregg L; Agani, Faton; Booth, Greg; Forsythe, Jo; Iyer, Narayan; Jiang, Bing-Hua; Leung, Sandra; Roe, Rick; Wiener, Charles; Yu, Aimee


Book ID
109885043
Publisher
Nature Publishing Group
Year
1997
Tongue
English
Weight
325 KB
Volume
51
Category
Article
ISSN
0085-2538

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## Abstract Hypoxia‐inducible factor 1 (HIF‐1) is a transcriptional activator that mediates adaptive responses to hypoxia. HIF‐1 activity is increased in the majority of human cancers as a result of genetic alterations and intratumoral hypoxia. HIF‐1 activates the transcription of genes that increa