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Hypoxia-inducible factor 1 and cancer pathogenesis

✍ Scribed by Gregg L. Semenza

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
235 KB
Volume
60
Category
Article
ISSN
1521-6543

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✦ Synopsis

Abstract

Hypoxia‐inducible factor 1 (HIF‐1) is a transcriptional activator that mediates adaptive responses to hypoxia. HIF‐1 activity is increased in the majority of human cancers as a result of genetic alterations and intratumoral hypoxia. HIF‐1 activates the transcription of genes that increase O~2~ availability by stimulating angiogenesis or that reprogram cellular metabolism to adapt to reduced O~2~ availability. Proof of principle studies in mouse models suggests that inhibition of HIF‐1 activity may have therapeutic effects, especially in combination with other anticancer drugs. © 2008 IUBMB IUBMB Life, 60(9): 591–597, 2008

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