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Hypoxia-inducible factor-1 and oncogenic signalling

✍ Scribed by Julia I. Bárdos; Margaret Ashcroft

Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
154 KB
Volume
26
Category
Article
ISSN
0265-9247

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✍ Gregg L. Semenza 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 235 KB

## Abstract Hypoxia‐inducible factor 1 (HIF‐1) is a transcriptional activator that mediates adaptive responses to hypoxia. HIF‐1 activity is increased in the majority of human cancers as a result of genetic alterations and intratumoral hypoxia. HIF‐1 activates the transcription of genes that increa