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Structural and Biochemical Studies of Inhibitor Binding to Human Cytomegalovirus Protease †

✍ Scribed by Khayat, Reza; Batra, Renu; Qian, Chungeng; Halmos, Teddy; Bailey, Murray; Tong, Liang


Book ID
126808487
Publisher
American Chemical Society
Year
2003
Tongue
English
Weight
612 KB
Volume
42
Category
Article
ISSN
0006-2960

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A weak inhibitor means faster exchange! Since the methyl ketone MK2 is a weak noncovalent peptidyl inhibitor of the human cytomegalovirus protease, exchange between the free and enzyme-bound forms is rapid. This allows for the use of transferred NOE NMR methods and molecular modeling, which show tha