✦ LIBER ✦

Evidence of a Conformational Change in the Human Cytomegalovirus Protease upon Binding of Peptidyl-Activated Carbonyl Inhibitors

✍ Scribed by Bonneau, Pierre R.; Grand-Maître, Chantal; Greenwood, Daniel J.; Lagacé, Lisette; LaPlante, Steven R.; Massariol, Marie-Josée; Ogilvie, William W.; O'Meara, Jeff A.; Kawai, Stephen H.

Book ID: 127332201
Publisher: American Chemical Society
Year: 1997
Tongue: English
Weight: 388 KB
Volume: 36
Category: Article
ISSN: 0006-2960
DOI: 10.1021/bi970366x

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

The Conformation of a Peptidyl Methyl Ke

The Conformation of a Peptidyl Methyl Ketone Inhibitor Bound to the Human Cytomegalovirus Protease

✍ Steven R. LaPlante; Dale R. Cameron; Norman Aubry; Pierre R. Bonneau; Robert Déz 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 148 KB 👁 2 views

A weak inhibitor means faster exchange! Since the methyl ketone MK2 is a weak noncovalent peptidyl inhibitor of the human cytomegalovirus protease, exchange between the free and enzyme-bound forms is rapid. This allows for the use of transferred NOE NMR methods and molecular modeling, which show tha

Conformational Changes in Human Hepatiti

Conformational Changes in Human Hepatitis C Virus NS3 Protease upon Binding of Product-Based Inhibitors †

✍ Bianchi, Elisabetta; Orrù, Stefania; Dal Piaz, Fabrizio; Ingenito, Raffaele; Cas 📂 Article 📅 1999 🏛 American Chemical Society 🌐 English ⚖ 140 KB

Detection of a High-Barrier Conformation

Detection of a High-Barrier Conformational Change in the Active Site of Cytochrome P450 cam upon Binding of Putidaredoxin

✍ Wei, Julie Y.; Pochapsky, Thomas C.; Pochapsky, Susan Sondej 📂 Article 📅 2005 🏛 American Chemical Society 🌐 English ⚖ 131 KB

Conformational changes in phospholipase

Conformational changes in phospholipase A2 upon binding to micellar interfaces in the absence and presence of competitive inhibitors. A proton and nitrogen-15 NMR study

✍ Peters, Anton R.; Dekker, Niek; Van den Berg, Lambertus; Boelens, Rolf; Kaptein, 📂 Article 📅 1992 🏛 American Chemical Society 🌐 English ⚖ 750 KB

N -Tosyl- l -phenylalanine Chloromethyl

N -Tosyl- l -phenylalanine Chloromethyl Ketone, a Serine Protease Inhibitor, Identifies Glutamate 398 at the Coenzyme-Binding Site of Human Aldehyde Dehydrogenase. Evidence for a Second “Naked Anion” at the Active Site †

✍ Dryjanski, Marek; Kosley, Lynda L.; Pietruszko, Regina 📂 Article 📅 1998 🏛 American Chemical Society 🌐 English ⚖ 132 KB

Post-translational Modifications of Huma

Post-translational Modifications of Human Thrombin-Activatable Fibrinolysis Inhibitor (TAFI): Evidence for a Large Shift in the Isoelectric Point and Reduced Solubility upon Activation †

✍ Valnickova, Zuzana; Christensen, Trine; Skottrup, Peter; Thøgersen, Ida B.; Højr 📂 Article 📅 2006 🏛 American Chemical Society 🌐 English ⚖ 244 KB