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Structural analysis of inhibitor binding to HIV-1 protease: identification of a common binding motif

✍ Scribed by D.G. Covell; R.L. Jernigan; A. Wallqvist

Book ID
114142606
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
323 KB
Volume
423
Category
Article
ISSN
0166-1280

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The effects of the peptide inhibitor acetyl pepstatin on the structural stability of the HIV-1 protease have been measured by high sensitivity calorimetric techniques. At 25Β°C and pH 3.6, acetyl pepstatin binds to HIV-1 protease with an affinity of 1.6 Ψ‹ 10 7 M -1 and an enthalpy of 7.3 ؎ 0.5 kcal/m