Structural analysis of the mouse T-cell receptorTcra V2subfamily

✍ Scribed by Kai Wang; Chia-Lam Kou; Kuang-Chuan Cheng; Mi-Kyung Lee; Bryan Paeper; Ben F. Koop; Tai-June Yoo; Leroy Hood

• Book ID: 104656146
• Publisher: Springer-Verlag
• Year: 1994
• Tongue: English
• Weight: 711 KB
• Volume: 40
• Category: Article
• ISSN: 0093-7711
• DOI: 10.1007/bf00188174

✦ Synopsis

Cosmid clones containing T-cell receptor Tcra V2 subfamily gene segments have been isolated from a BALB/ c cosmid library and subjected to DNA sequence analysis. The V gene segments in the Tcra V2 subfamily differ from each other by 3%-7% at the nucleotide level and 5% -16% at the amino acid level. T-cell receptor Tcra V2 gene segment polymorphisms have been identified in the B10.PL and PL/J mouse strains with a Tera V2 subfamily-specific probe. These V gene segment polymorphisms may cause the differential Tcra V gene usage in induced experimental allergic encephalomyelitis between B 10.PL and PL/J mice.