Striatal and Extrastriatal Dopamine D2/D3 Receptors in Schizophrenia Evaluated With [18F]fallypride Positron Emission Tomography
โ Scribed by Lawrence S. Kegeles; Mark Slifstein; Xiaoyan Xu; Nina Urban; Judy L. Thompson; Tiffany Moadel; Jill M. Harkavy-Friedman; Roberto Gil; Marc Laruelle; Anissa Abi-Dargham
- Book ID
- 119198636
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 263 KB
- Volume
- 68
- Category
- Article
- ISSN
- 0006-3223
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
[(18)F]Fallypride is a highly selective, high-affinity dopamine D-2 receptor ligand. The high affinity, K(D) = 30 pM, makes it a suitable candidate for visualizing both striatal and extrastriatal binding in the brain. In this work, dynamic PET studies of two macaque monkeys were acquired along with
We have investigated the ability of dopamine to compete with the binding of the high affinity dopamine D 2 receptor positron emission tomography (PET) radioligand, 18 F-fallypride. In vitro dissociation of 18 F-fallypride with dopamine in rat striatal homogenates exhibited a dissociation rate, k off