Oxidative stress is involved in diabetes mellitus and its complications. Selenium is a nutritional antioxidant, especially because it is required for the activity of seleniumdependent glutathione peroxidase. Selenium also may have insulin-like properties and improve insulin sensitivity. However, its
Streptozotocin induced diabetic nephropathy and renal tumors in the rat
β Scribed by A. F. Bleasel; L. C. J. Yong
- Publisher
- Springer
- Year
- 1982
- Tongue
- English
- Weight
- 756 KB
- Volume
- 38
- Category
- Article
- ISSN
- 1420-682X
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## Abstract **Scope**: We hypothesized that curcumin, a potent antiβoxidant, might be beneficial in ameliorating the development of diabetic nephropathy through inhibition of PKCβΞ± and PKCβΞ²1 activityβERK1/2 pathway. **Methods and results**: Diabetes was induced by a single intraperitoneal injecti