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Strategies to circumvent the T315I gatekeeper mutation in the Bcr-Abl tyrosine kinase

โœ Scribed by Bose, Prithviraj; Park, Haeseong; Al-Khafaji, Jawad; Grant, Steven


Book ID
121080252
Publisher
Elsevier
Year
2013
Tongue
English
Weight
174 KB
Volume
2
Category
Article
ISSN
2213-0489

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## Abstract We analysed the dynamic change of imatinibโ€resistant mutations in BCRโ€ABL kinase domain focusing on T315I mutation during dasatinib or nilotinib therapy. Fiftyโ€five imatinibโ€resistant chronic myeloid leukaemia patients (32 patients with imatinibโ€resistant mutations and 23 patients witho