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Allosteric inhibition enhances the efficacy of ABL kinase inhibitors to target unmutated BCR-ABL and BCR-ABL-T315I

โœ Scribed by Afsar Ali Mian, Anna Metodieva, Susanne Badura, Mamduh Khateb, Nili Ruimi, Yousef Najajreh, Oliver Gerhard Ottmann, Jamal Mahajna, Martin Ruthardt


Book ID
119897455
Publisher
BioMed Central
Year
2012
Tongue
English
Weight
389 KB
Volume
12
Category
Article
ISSN
1471-2407

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## Abstract We analysed the dynamic change of imatinibโ€resistant mutations in BCRโ€ABL kinase domain focusing on T315I mutation during dasatinib or nilotinib therapy. Fiftyโ€five imatinibโ€resistant chronic myeloid leukaemia patients (32 patients with imatinibโ€resistant mutations and 23 patients witho