## Abstract In chronic myeloid leukemia (CML), BCR/ABL‐mediated oncogenic signaling can be targeted with the BCR/ABL‐inhibitors Imatinib, Nilotinib and Dasatinib. However, these agents may also affect anti‐tumor immunity. Here, we analyzed the effects of the 3 BCR/ABL‐inhibitors on natural killer (
✦ LIBER ✦
Target spectrum of the BCR-ABL inhibitors imatinib, nilotinib and dasatinib
✍ Scribed by Hantschel, Oliver; Rix, Uwe; Superti-Furga, Giulio
- Book ID
- 115317280
- Publisher
- Informa plc
- Year
- 2008
- Tongue
- English
- Weight
- 441 KB
- Volume
- 49
- Category
- Article
- ISSN
- 1042-8194
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## Abstract Because imatinib (IM) resistance in chronic myeloid leukemia is primarily caused by the re‐establishment of Abl kinase, new inhibitors may be efficacious. We evaluated 3 new agents against 2 new K562 variants, IM‐R1 and IM‐R2 cells, which were developed having 7‐ and 27‐fold greater IM