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Strategies for the selection of catalytic antibodies against organophosphorus nerve agents

✍ Scribed by Smirnov, Ivan; Belogurov, Alexey; Friboulet, Alain; Masson, Patrick; Gabibov, Alexander; Renard, Pierre-Yves


Book ID
119952240
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
607 KB
Volume
203
Category
Article
ISSN
0009-2797

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Haptens bearing phosphorane and c~-hydroxyphosphinate structures have been designed and synthesized for the selection of monoclonal antibodies with phosphatase like activity in order to detoxify highly toxic organophosphorus chemical weapons such as VX.