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Strategies for selection of antibodies by phage display

✍ Scribed by Andrew D Griffiths; Alexander R Duncan

Book ID: 104362140
Publisher: Elsevier Science
Year: 1998
Tongue: English
Weight: 689 KB
Volume: 9
Category: Article
ISSN: 0958-1669
DOI: 10.1016/s0958-1669(98)80092-x

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✦ Synopsis

Phage antibody-display is rapidly maturing into a very effective tool for antibody generation. The recent development of large primary antibody libraries enables selection of antibodies against most targets in under two weeks and many of these antibodies have relatively high (nanomolar) affinities. Successful strategies have also been developed to affinity mature these antibodies into the picomolar range if required.

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