Strategies for Increasing the Sensitivity of Gadolinium Based MRI Contrast Agents
โ Scribed by Peter Caravan
- Publisher
- John Wiley and Sons
- Year
- 2006
- Weight
- 8 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0931-7597
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Unique paramagnetic liposomal contrast agents were synthesized and utilized for selective augmentation of TI MR imaging of the livers of normal Balb/c mice. Amphipathic gadolinium complexes, which mimic phospholipids, were incorporated into the lamella of small unilamellar liposomes (SUV) such that
## on the occasion of his 60th birthday The utility of clinical magnetic resonance imaging (MRI) has been greatly expanded by the use of contrast agentsgadolinium complexes that serve to increase the longitudinal nuclear relaxation rate (1/T 1 ) of water protons. Commercial contrast agents are only