✦ LIBER ✦

Gadolinium-labeled liposomes containing paramagnetic amphipathic agents: Targeted MRI contrast agents for the liver

✍ Scribed by G. W. Kabalka; E. Buonocore; K. Hubner; M. Davis; L. Huang

Publisher: John Wiley and Sons
Year: 1988
Tongue: English
Weight: 430 KB
Volume: 8
Category: Article
ISSN: 0740-3194
DOI: 10.1002/mrm.1910080111

No coin nor oath required. For personal study only.

✦ Synopsis

Unique paramagnetic liposomal contrast agents were synthesized and utilized for selective augmentation of TI MR imaging of the livers of normal Balb/c mice. Amphipathic gadolinium complexes, which mimic phospholipids, were incorporated into the lamella of small unilamellar liposomes (SUV) such that they became an integral part of its surface. T 1 signal enhancement of normal liver approached 150% after iv administration of the paramagnetic liposomes, determined by experiments performed on a 1.9-T, experimental whole-body MRI unit. Tracer studies utilizing gadolinium-153-tagged SUV revealed that the agents exhibited excellent in vivo stability, compared to liposomal preparations in which paramagnetic agents are simply entrapped in the aqueous core of the IipOSOme vesicle.

📜 SIMILAR VOLUMES

Gadolinium labeled pharmaceuticals as po

Gadolinium labeled pharmaceuticals as potential mri contrast agents for liver and biliary tract

✍ A. Najafi; E. E. Amparo; R. R. Johnson Jr. 📂 Article 📅 1987 🏛 John Wiley and Sons 🌐 French ⚖ 480 KB

Three gadolinium-labeled compounds, potential nuclear magnetic resonance (hTlR) imaging contrast agents for liver and biliary tract, were studied: I ) Gd-DISIDA, 2 ) Gd-DTPA-Liposomes, and 3 ) Gd-DTPA dihexadecylamide (Gd-diamide). In each case, "Carrier Added" Gd-153 with specific activity of about