Development of Intravascular Contrast Agents for MRI Using Gadolinium Chelates
β Scribed by Krisada Kittigowittana; Dr. Chang-Tong Yang; Dr. Wai Ching Cheah; Dr. Kai-Hsiang Chuang; Chew-Yuan Tuang; Prof. Young-Tae Chang; Dr. Xavier Golay; Prof. Roderick W. Bates
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 326 KB
- Volume
- 6
- Category
- Article
- ISSN
- 1860-7179
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## Abstract ## Purpose To test whether Bβ22956/1, a novel intravascular contrast agent with a high affinity to serum albumin (Bracco Imaging SpA.), allowed quantifying neovessel and macrophage density in atherosclerotic plaques of rabbits using MRI. ## Materials and Methods A T1βweighted MRI of
Dipolar interaction between the metal ion and proximate water molecules represents an efficient mechanism for solvent relaxation in Gd 3+ complexes currently employed as MRI contrast agents. Besides inner sphere (metal bound) and outer sphere hydration molecules, a well-defined second coordination s