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Second Coordination Sphere Water Molecules and Relaxivity of Gadolinium(III) Complexes: Implications for MRI Contrast Agents

✍ Scribed by Mauro Botta

Publisher: John Wiley and Sons
Year: 2000
Tongue: English
Weight: 603 KB
Volume: 2000
Category: Article
ISSN: 1434-1948
DOI: 10.1002/(sici)1099-0682(200003)2000:3<399::aid-ejic399>3.0.co;2-b

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✦ Synopsis

Dipolar interaction between the metal ion and proximate water molecules represents an efficient mechanism for solvent relaxation in Gd 3+ complexes currently employed as MRI contrast agents. Besides inner sphere (metal bound) and outer sphere hydration molecules, a well-defined second coordination shell may provide an additional mechanism for paramagnetic relaxation leading to a strong enhancement of the relaxivity of the complexes. Through a careful choice of hydrogen-bond-acceptor groups on the ligand we may: (1) promote the formation of a strong interaction; (2) increase the number of water molecules in the second hydration shell; (3)

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