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Strategies for cyclizations of novel peptides on solid supports

✍ Scribed by Victor J. Hruby; Susanne Wilke; Fahad Al-Obeidi; Ding Jiao; Ying Lin


Publisher
Elsevier Science
Year
1994
Weight
857 KB
Volume
22
Category
Article
ISSN
0923-1137

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## Abstract A 22‐residue peptide with a sidechain lactam bridge involving 18 residues (60‐atom cycle) has been synthesized. Three different protection schemes using Fmoc/^t^Bu/cyclohexyl, Fmoc/^t^Bu/allyl or Boc/Bzl/ fluorenylmethyl protecting group combinations have been explored for the solid pha