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A novel core-shell type polymer support for solid-phase peptide synthesis

✍ Scribed by Jin Ku Cho; Byeong-Deog Park; Yoon-Sik Lee

Publisher
Elsevier Science
Year
2000
Tongue
French
Weight
128 KB
Volume
41
Category
Article
ISSN
0040-4039

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πŸ“œ SIMILAR VOLUMES

Preparation of a core–shell type MBHA re
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## a-Amidoalkylation Partial hydrolysis Solid-phase peptide synthesis a b s t r a c t MBHA (4-methylbenzhydrylamine) resin has been extensively used as a solid support for the synthesis of peptide amides. Herein, we prepared the core-shell-type MBHA resin by benzotriazole-catalyzed amidoalkylation

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A novel symmetrical dendrimer monomer was synthesized from tris(hydroxymethyl)aminomethane (Tris) and repeatedly coupled to a core-shell type resin. The loading capacity of amino groups was increased up to 4.0 mmol g -1 resin by the dendrimerization process. The high loading dendrimer-grafted resin