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Straightforward Access to (Imidazol-2-yl)acetates by Reaction of 2-Unsubstituted Imidazole 3-Oxides with Dimethyl Acetylenedicarboxylate

✍ Scribed by Grzegorz Mlostoń; Marcin Jasiński; Heinz Heimgartner

Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
177 KB
Volume
2011
Category
Article
ISSN
1434-193X

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✦ Synopsis

Abstract

A new method for the preparation of 1,4,5‐trisubstituted (imidazol‐2‐yl)acetates, based on the reaction of the corresponding imidazole 3‐oxides with dimethyl acetylenedicarboxylate (DMAD) is described. Formation of the products is rationalized by a formal 1,3‐dipolar cycloaddition and subsequent oxaloyl cleavage.

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ChemInform Abstract: Straightforward Acc
ChemInform Abstract: Straightforward Access to (Imidazol-2-yl)acetates by Reaction of 2-Unsubstituted Imidazole 3-Oxides with Dimethyl Acetylenedicarboxylate.
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## Abstract The formation of the desired imidazoles is rationalized by a formal 1,3‐dipolar cycloaddition reaction followed by an oxaloyl cleavage of oxobutanoate intermediates (III).

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## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.