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ChemInform Abstract: Straightforward Access to (Imidazol-2-yl)acetates by Reaction of 2-Unsubstituted Imidazole 3-Oxides with Dimethyl Acetylenedicarboxylate.

✍ Scribed by Grzegorz Mloston; Marcin Jasinski; Heinz Heimgartner

Publisher
John Wiley and Sons
Year
2011
Weight
28 KB
Volume
42
Category
Article
ISSN
0931-7597

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✦ Synopsis

Abstract

The formation of the desired imidazoles is rationalized by a formal 1,3‐dipolar cycloaddition reaction followed by an oxaloyl cleavage of oxobutanoate intermediates (III).

📜 SIMILAR VOLUMES

Straightforward Access to (Imidazol-2-yl
Straightforward Access to (Imidazol-2-yl)acetates by Reaction of 2-Unsubstituted Imidazole 3-Oxides with Dimethyl Acetylenedicarboxylate
✍ Grzegorz Mlostoń; Marcin Jasiński; Heinz Heimgartner 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 177 KB

## Abstract A new method for the preparation of 1,4,5‐trisubstituted (imidazol‐2‐yl)acetates, based on the reaction of the corresponding imidazole 3‐oxides with dimethyl acetylenedicarboxylate (DMAD) is described. Formation of the products is rationalized by a formal 1,3‐dipolar cycloaddition and s